Observational analysis demonstrating how circ-UBR5 enhances metastasis via HNRNPR in lung adenocarcinoma, highlighting potential biomarkers.
The circ-UBR5-HNRNPR axis is a critical regulatory mechanism driving LUAD metastasis. Hypoxic LUAD cells deliver circ-UBR5 to normoxic cells via exosomes, thereby enhancing the metastatic potential of normoxic LUAD cells. This process is mediated by circ-UBR5 binding to HNRNPR. High expression of circ-UBR5 and HNRNPR in tumor tissues correlates with poor prognosis in patients with LUAD, indicating their potential as novel prognostic biomarkers and therapeutic targets for LUAD.
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Lin et al. (2026) studied this question.
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