Aim: This study aimed to systematically evaluate the effects of resveratrol (RSV) supplementation on renal injury-related indicators in patients with type 2 diabetes mellitus (T2DM). Data Synthesis: This systematic review and meta-analysis included 12 randomized controlled trials (RCTs) with a total of 636 participants with type 2 diabetes. The analysis was conducted exclusively on RCTs to ensure the highest quality of evidence. The pooled results demonstrated no significant changes in blood urea nitrogen (WMD: – 0.01; 95% CI: – 0.66 to 0.63; P = 0.97) or serum creatinine (SMD: 0.05; 95% CI: – 0.13 to 0.23; P = 0.56). Subgroup analyses revealed no significant differences regardless of RSV dose or intervention duration. In contrast, RSV supplementation resulted in a modest reduction in serum uric acid of − 0.42 mg/dL (WMD: – 0.42; 95% CI: – 0.65 to – 0.18; P = 0.0005), with low heterogeneity among the included studies (I 2 = 0%). Conclusion: This systematic review and meta-analysis provides updated evidence that RSV significantly reduces serum UA levels in patients with T2DM, despite having no significant effects on BUN and SCr. This specific urate-lowering effect suggests a potential role for RSV in managing hyperuricemia, a common comorbidity in T2DM that contributes to renal and cardiovascular risk. Systematic Review Registration: PROSPERO CRD420251033457. Keywords: resveratrol, type 2 diabetes, uric acid, blood urea nitrogen, serum creatinine, meta-analysis
Gu et al. (Thu,) studied this question.