A significant association exists between IgA+ and GZMB+ Bregs, indicating a potential mechanism for tolerance.
Assessment of B cell populations reveals that higher GZMB expression correlates with greater suppressive effects.
Findings highlight the importance of IgA-producing B cells in promoting tolerance through granzyme B activity.
Abstract
These data show a strong association between IgA+ and GZMB+ Bregs, particularly in tolerant kidney transplant recipients with higher GZMB and IgA expression and greater suppressive properties.