Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors

Marco De Zuani; Petra Lázničková; Marcela Hortová Kohoutková; Veronika Bosáková; Ivana Andrejčinová; Natália Vadovičová; Veronika Tomášková; Alexandra Mýtniková; Julie Štíchová; Tomáš Tomáš; Jiří Hrdý; Kristýna Boráková; Stjepan Uldrijan; Marcela Vlková; Vladimír Šrámek; Martin Helán; Kamila Bendíčková; Jan Frič

doi:10.1186/s12950-025-00483-5

Key Points

Long-term reprogramming of human hematopoietic stem and progenitor cells (HSPCs) drives myeloid dysregulation.
Sepsis survivors exhibit altered immune memory that may impact their overall immune response.
Assessment of immune alterations in this population reveals potential therapeutic avenues to explore.
Identifying specific reprogramming pathways in HSPCs may guide better management of sepsis long-term outcomes.

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Implication

Observational analysis uncovers immune dysregulation in sepsis survivors, indicating new management targets.

Abstract

Together, these findings suggest that sepsis induces lasting reprogramming in HSPCs leading to myeloid progeny with altered immune memory that might drive immune dysregulation in survivors. These data open avenues to explore potential targets to better manage long-term immune alterations in sepsis survivors.

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Zuani et al. (2026) studied this question.

synapsesocial.com/papers/69a75ab8c6e9836116a20e4b https://doi.org/10.1186/s12950-025-00483-5

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Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors

Key Points

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Implication

Abstract

Discussion

Cite This Study

Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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