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January 27, 2026Indian Journal of Hematology and Blood Transfusion

Anaplastic Lymphoma Kinase—Positive Large B Cell Lymphoma: An Underdiagnosed Entity

Pritinanda Mishra J. N. Aparnna Chinmayee Panigrahi Tapas Kanti Parida Somanath Padhi Ashutosh Panigrahi Mukund N. Sable

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Key Points

The underdiagnosis of anaplastic lymphoma kinase-positive large B cell lymphoma has clinical implications for treatment.
Increased awareness and better diagnostic criteria are essential to identify more cases effectively.
Enhanced understanding of the molecular pathways involved may lead to improved therapeutic strategies for patients.
Further studies are required to validate biomarkers associated with anaplastic lymphoma kinase-positive large B cell lymphoma.

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Implication

Observational analysis reveals underdiagnosed anaplastic lymphoma kinase-positive large B cell lymphoma, suggesting need for increased awareness.

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Cite This Study

Mishra et al. (2026) studied this question.

synapsesocial.com/papers/69a75abec6e9836116a20f43 https://doi.org/10.1007/s12288-026-02322-w

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Synapse has enriched 5 related papers. Consider them for comparative context:

1A New Subtype of Large B-Cell Lymphoma Expressing the ALK Kinase and Lacking the 2; 5 TranslocationOriginal Research · 1997 · 343 citations
2Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK + LBCL): a systematic review of clinicopathological features and managementPrognostic Study · 2021 · 23 citations
3ALK-positive Large B-cell LymphomaReview · 2016 · 87 citations
4Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemiaOriginal Research · 2010 · 32 citations
5Clinical Utility of the Chromogenic Anti-Factor Xa Assay When the aPTT is Unreliable: Four Illustrative CasesIndian Journal of Hematology and Blood Transfusion · Fri,

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