Do epileptic patients who respond to VNS exhibit different complex network behaviors compared to non-responders and healthy controls?
VNS responders show unique complex network behaviors, particularly in the alpha frequency band during hyperventilation, which may help differentiate them from non-responders.
The VNS responders exhibit more differences when compared to HCs than VNS non-responders. These differences can be observed in RPW, but they become more pronounced when Entropy analysis is applied. It seems that the distinct response to hyperventilation is present in both VNS responders and non-responders, differentiating them from HCs. However, the binding of this response to frequency bands differs among VNS responders and non-responders. In particular, the reaction among the VNS responders is strongly associated with the alpha frequency band.
Dolezalova et al. (Tue,) studied this question.