March 3, 2026Protein and Peptide Letters2 citations
Prolyl 4-Hydroxylase Beta Peptide Promotes Invasion, Migration, and Epithelial-Mesenchymal Transition through Activation of the Claudin-1/ AMPK/TGF-β1 Pathway in Bladder Cancer Cells
Invasion and migration of bladder cancer cells increased significantly after P4HB activation, indicating a strong pathway influence.
Key evidence includes alterations in Claudin-1, AMPK, and TGF-β1, which are critical in promoting epithelial-mesenchymal transition (EMT).
Analysis reveals activation of the Claudin-1/AMPK/TGF-β1 pathway through P4HB, crucial for cancer cell behavior and progression.
This finding supports the notion that targeting these molecular pathways may provide new treatment strategies for cancer patients, especially in advanced stages.
Abstract
P4HB promoted migration, invasion, and EMT of bladder cancer cells by activating the Claudin-1/AMPK/TGF-β1-related pathway.