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March 3, 2026Protein and Peptide Letters3 citations

Prolyl 4-Hydroxylase Beta Peptide Promotes Invasion, Migration, and Epithelial-Mesenchymal Transition through Activation of the Claudin-1/ AMPK/TGF-β1 Pathway in Bladder Cancer Cells

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MQMingning QiuSZShuai ZhangGuangdong Medical CollegeJLJinglan LiangGuangdong Medical College

Key Points

  • Invasion and migration of bladder cancer cells increased significantly after P4HB activation, indicating a strong pathway influence.
  • Key evidence includes alterations in Claudin-1, AMPK, and TGF-β1, which are critical in promoting epithelial-mesenchymal transition (EMT).
  • Analysis reveals activation of the Claudin-1/AMPK/TGF-β1 pathway through P4HB, crucial for cancer cell behavior and progression.
  • This finding supports the notion that targeting these molecular pathways may provide new treatment strategies for cancer patients, especially in advanced stages.

Abstract

P4HB promoted migration, invasion, and EMT of bladder cancer cells by activating the Claudin-1/AMPK/TGF-β1-related pathway.

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Cite This Study

Qiu et al. (2025) studied this question.

synapsesocial.com/papers/69a75ac3c6e9836116a20fc4https://doi.org/10.2174/0109298665418763251124051527
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges2019 · 1,377 citations
  2. 2Prognostic model development and molecular subtypes identification in bladder urothelial cancer by oxidative stress signatures2024 · 19 citations
  3. 3Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling2018 · 50 citations
  4. 4XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT2024 · 5 citations
  5. 5Cytokeratin 17 activates AKT signaling to induce epithelial-mesenchymal transition and promote bladder cancer progression2025 · 4 citations