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January 28, 2026European Journal of Pharmacology

Therapeutic effects of methotrexate encapsulated in hyaluronic acid-coated exosomes derived from Wharton's jelly mesenchymal stem cells in a rat model of rheumatoid arthritis

Zahra Akbari Jonoush Mahmoud Gharbavi Mehri Ghafourian Seyed Esmaeil Khoshnam Ali Khodadadi Farideh Khanom Farahbakhsh Afshin Amari

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Key Points

Methotrexate encapsulated in exosomes significantly reduces inflammation in the rat model of rheumatoid arthritis.
Treatment led to a 40% decrease in joint swelling within two weeks, indicating strong therapeutic potential.
Employing exosomes from Wharton's jelly mesenchymal stem cells allowed targeted delivery of the drug.
This approach may enable future advances in rheumatoid arthritis treatment strategies.

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Implication

Observational analysis reveals improved effects of methotrexate in a rat model of rheumatoid arthritis, suggesting innovative treatment methods.

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Cite This Study

Jonoush et al. (2026) studied this question.

synapsesocial.com/papers/69a75ac4c6e9836116a2104c https://doi.org/10.1016/j.ejphar.2026.178610

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