PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 3, 2026British Journal of Clinical Pharmacology0 citationsOpen Access

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

View Full Paper
DADanilo Alves‐BezerraLNLuiza B. NegreirosAPAmaury Pereira‐Acácio

Key Points

  • Valproic acid shows potential benefits in acute kidney injury outcomes, possibly preventing chronic kidney disease.
  • Improvement metrics involve its pharmacological properties and adjuvant role in treatment.
  • Analysis presented assessment using clinical outcomes related to acute kidney injury in diverse populations.
  • This insight highlights the need for further exploration into novel uses for existing medications, which could enhance kidney health.

Abstract

Valproate has pharmacological properties that point to its potential repositioning as an adjuvant in improving several outcomes in AKI and potentially avoiding progression to chronic kidney disease.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Alves‐Bezerra et al. (2026) studied this question.

synapsesocial.com/papers/69a75ae1c6e9836116a2149fhttps://doi.org/10.1002/bcp.70456
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup2017 · 1,564 citations
  2. 2Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis2013 · 59 citations
  3. 3Drug repositioning: identifying and developing new uses for existing drugs2004 · 3,298 citations
  4. 4Biomarkers and predicting acute kidney injury2020 · 93 citations
  5. 5Plasma creatinine determination in mice and rats: An enzymatic method compares favorably with a high-performance liquid chromatography assay2006 · 138 citations