Stepwise Depletion of CD27+IgD+ B Cells Correlates With Fibrosis Progression to Cirrhosis in HBV-Infected Patients

Key Points

• Cirrhosis progression correlates with CD27+IgD+ B cell depletion, highlighting the potential role of immune markers.
• The depletion of CD27+IgD+ B cells was found to correlate significantly with fibrosis stages and progression.
• Assessment involved a cohort of HBV-infected patients, indicating possible immune response mechanisms in fibrosis.
• Recognizing CD27+IgD+ B cells as biomarkers may enable better risk stratification and monitoring in HBV disease progression.