Stepwise Depletion of CD27+IgD+ B Cells Correlates With Fibrosis Progression to Cirrhosis in HBV-Infected Patients

Jinwei Wu; Cailing Wei; Yaqin Qin; Ping Cen; Zhenwei Wei; Weixin Li; Siying Lu; Xiaofan Fu; Yanping Fu; Wanli Cheng; Chunhua Jiang; Liang Li; Feng luo; Xiaodong Huang; Wanyun Tan; Yuhong Luo; Fen Li; Man Huang

doi:10.1016/j.jceh.2026.103490

Key Points

Cirrhosis progression correlates with CD27+IgD+ B cell depletion, highlighting the potential role of immune markers.
The depletion of CD27+IgD+ B cells was found to correlate significantly with fibrosis stages and progression.
Assessment involved a cohort of HBV-infected patients, indicating possible immune response mechanisms in fibrosis.
Recognizing CD27+IgD+ B cells as biomarkers may enable better risk stratification and monitoring in HBV disease progression.

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Implication

Observational analysis shows fibrosis progression correlates to CD27+IgD+ B cell depletion in HBV-infected individuals, suggesting a potential biomarker.

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Wu et al. (2026) studied this question.

synapsesocial.com/papers/69a75aefc6e9836116a21691 https://doi.org/10.1016/j.jceh.2026.103490

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Stepwise Depletion of CD27+IgD+ B Cells Correlates With Fibrosis Progression to Cirrhosis in HBV-Infected Patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Stepwise Depletion of CD27+IgD+ B Cells Correlates With Fibrosis Progression to Cirrhosis in HBV-Infected Patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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