Integrated multi-tissue transcriptome and serum metabolome analysis reveals brain–gut–liver regulatory axes of residual feed intake in ducks

Key Points

• Residual feed intake is influenced by brain–gut–liver regulatory axes, showing a complex interplay between these systems.
• The analysis revealed significant connections across 10 distinct metabolic pathways, enhancing our understanding of efficiency in feed utilization.
• Integrated multi-tissue transcriptome and serum metabolome analysis provides insights into metabolic regulation in ducks.
• Implications of these findings could enhance poultry nutrition strategies and improve feed efficiency in farming.