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March 3, 2026Frontiers in Microbiology4 citationsOpen Access

Disease-driven restructuring of the gut microbiome underlies inflammatory bowel disease dysbiosis

ZDZixu DingKRKe RenYXYixue Xu

Key Points

  • Dysbiosis in IBD patients features enriched inflammation-related pathways and reduced metabolic flexibility.
  • Patients exhibit alterations in gut microbiota that correlate with disease severity and inflammation levels.
  • Assessment using comparative microbiome analysis highlights shifts in microbial composition linked to IBD.
  • These findings may enable targeted therapies to restore gut microbiome balance and alleviate inflammation.

Abstract

Compared with healthy individuals, the gut microbiota of IBD patients undergoes functional reprogramming characterized by loss of metabolic versatility and enrichment of inflammation-related pathways. These findings provide new insights into the ecological and metabolic mechanisms through which the gut microbiota contribute to intestinal inflammation and disease progression.

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Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/69a75b18c6e9836116a21c5chttps://doi.org/10.3389/fmicb.2025.1744574
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