Immunotherapy-driven remodeling of the tumor immune microenvironment: Spatiotemporal heterogeneity and multidimensional dynamics

Key Points

• Immunotherapy remodeling significantly alters the tumor immune microenvironment, impacting immune response.
• A key metric reveals alterations in immune cell populations, indicating spatiotemporal heterogeneity over time.
• Observational analysis of immune responses across different time points provides insights into dynamic changes.
• These findings suggest that understanding this multi-faceted process is critical for optimizing immunotherapy strategies.