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January 27, 2026Clinical Drug InvestigationOpen Access

Efficacy of Brexpiprazole in Participants with Agitation Associated with Dementia Due to Alzheimer’s Disease: Pooled Analysis of Randomized Controlled Trials

Jeffrey L. Cummings Sanjeda R. Chumki Denise Chang Zhen Zhang Malaak Brubaker Nanco Hefting Pedro Such David Wang George T. Grossberg

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Key Points

Brexpiprazole shows a significant reduction in agitation associated with dementia.
In pooled analyses of trials, participants demonstrated improved scores for agitation symptoms.
This analysis involved a comprehensive review of randomized controlled trials focused on Alzheimer's-related agitation.
Findings suggest brexpiprazole may enable better management strategies for agitation in dementia patients.

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Implication

Pooled analysis reveals brexpiprazole reduces agitation in dementia, indicating potential for better management.

Abstract

ClinicalTrials.gov identifiers: NCT01862640, NCT03548584, and NCT01922258.

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Cite This Study

Cummings et al. (2026) studied this question.

synapsesocial.com/papers/69a75b41c6e9836116a22416 https://doi.org/10.1007/s40261-025-01517-9

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