Artesunate–pyronaridine–atovaquone–proguanil and artesunate–fosmidomycin–clindamycin compared with standard artesunate–pyronaridine for the treatment of uncomplicated malaria (MultiMal): a randomised, controlled, clinical, phase 2 trial in Gabon and Ghana

Key Points

• Artesunate combined with pyronaridine, atovaquone, and proguanil shows effectiveness against malaria.
• The trial included participants from Gabon and Ghana over a defined timeframe to assess treatment responses.
• Randomised controlled trial methodology establishes a solid evidence base on treatment efficacy in malaria cases.
• Findings indicate that alternative drug combinations may provide improved treatment options for uncomplicated malaria.