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January 27, 2026Journal of Pharmaceutical Sciences

Quantitative prediction of human metabolites formed from the oxidation of the alcohol group of the glucokinase activator, TMG-123, using chimeric mice with humanized livers

Akiko Watanabe Seishiro Sakamoto Shigeru Ohta Seigo Sanoh

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Key Points

Metabolites generated from TMG-123 oxidation were quantitatively predicted, providing new insights into metabolic processes.
Key findings indicate the formation of several specific metabolites resulting from the oxidation of the alcohol group.
Analysis using chimeric mice with humanized livers modeled human metabolic pathways effectively, enhancing relevance.
Study highlights the potential for improved understanding of drug metabolism and therapeutic implications in humans.

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Implication

Observational analysis predicts metabolites formed by TMG-123 oxidation in chimeric mice, suggesting insights into human metabolism.

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Cite This Study

Watanabe et al. (2026) studied this question.

synapsesocial.com/papers/69a75b45c6e9836116a224f0 https://doi.org/10.1016/j.xphs.2026.104177

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