Epigenetics in Abdominal Aortic Aneurysm: Mechanisms and Risk Prediction

Key Points

• Causal DNA methylation markers were identified, linking epigenetics to abdominal aortic aneurysm risk.
• AP-1-linked inflammatory transcription programs and blood lipids counted among key risk factors for AAA.
• Multi-omics analyses assessed various immune and inflammation-related proteins associated with AAA risk.
• Understanding these mechanisms may contribute to improved risk prediction and preventative strategies.