SHP2 regulates VEGFR2 Y1175/PLCγ signaling to impair tumor endothelial barrier stability

Key Points

• Endothelial barrier stability is impaired by SHP2's regulation of VEGFR2 signaling pathway.
• SHP2 negatively affects vascular permeability, emphasizing its role in tumor progression.
• Analysis of PLCγ signaling indicates its involvement in the destabilization of the endothelial barrier.
• This finding highlights potential avenues for targeted therapies in enhancing tumor endothelial integrity.