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March 3, 2026Photodiagnosis and Photodynamic Therapy2 citationsOpen Access

Efficacy and safety of photodynamic therapy for vaginal intraepithelial neoplasia: A systematic review and meta-analysis

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XWXu WangJLJiapei LiXLXiaofang Li

Key Points

  • Photodynamic therapy shows high efficacy and a favorable safety profile in treating vaginal intraepithelial neoplasia.
  • The analysis of single-arm studies indicates significant effectiveness of ALA-PDT over traditional therapies.
  • A systematic review aggregated data to assess the safety and effectiveness of photodynamic therapy.
  • Future multicenter randomized controlled trials are crucial to validate findings and ensure robustness.

Abstract

ALA-PDT demonstrates high efficacy and favorable safety in treating VaIN. However, as current evidence primarily stems from single-arm studies, future high-quality multicenter randomized controlled trials are essential to confirm these findings and directly compare ALA-PDT with standard therapies.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a75b5dc6e9836116a228fdhttps://doi.org/10.1016/j.pdpdt.2026.105340
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