Clarifying the immunoglobulin light chain variable gene usage in Chinese patients with renal AL amyloidosis

Puntos clave

• Severe kidney structural damage is linked to IGLV1 gene usage, impacting renal function significantly.
• Full nephrotic syndrome occurs more frequently in patients with IGLV6-57, suggesting a distinct phenotype.
• Assessment highlights the connection between specific immunoglobulin genes and clinicopathological features of AL amyloidosis.
• Findings indicate that IGLV1-51 usage may serve as a predictor of poor renal survival, warranting further investigation.

Resumen