Nano herbal therapeutics combine nanotechnology with herbal medicine to overcome challenges like poor bioavailability and instability of phytochemicals. These formulations enhance efficacy, safety, and patient compliance compared to conventional herbal and synthetic nanoparticle systems. Plant-derived nanoparticles (PDNPs) offer benefits including improved cellular uptake, low toxicity, eco-friendliness, and cost-effectiveness. Several nano-formulated herbal compounds have shown promising outcomes in preclinical and clinical studies, especially in cancer, inflammation, and metabolic disorders. This review highlights the pharmacokinetics, pharmacology, and therapeutic potential of nano-herbal systems while comparing PDNPs to synthetic counterparts. We also explore their mechanisms of action, molecular signaling pathways, and roles in targeted delivery. Additionally, the review addresses challenges such as formulation stability, large-scale production, regulatory gaps, and long-term toxicity. A systematic literature review was conducted using databases like PubMed, Scopus, and Web of Science. Emerging tools such as AI-assisted formulation and biodegradable carriers are discussed as future directions. The integration of nanotechnology and herbal medicine presents a transformative approach to disease treatment. However, regulatory standardization, environmental safety, and ethical commercialization remain critical for clinical translation.
Hassan et al. (Thu,) studied this question.