March 3, 2026Open Access

HPV11 targeting PPARA regulates the autophagy to inhibit the occurrence and development of nasal inverted papilloma

Key Points

Inhibiting autophagy reversed the PPARA-driven suppression of nasal inverted papilloma.
Key findings indicate that HPV11 promotes proliferation while also regulating autophagy through PPARA.
Analysis highlights the complex interaction between HPV11 integration and host cell mechanisms.
Potential implications for understanding HPV11's role in nasal inverted papilloma development and treatment strategies.

Abstract

HPV11 exerts dual effects on nasal mucosal cells: promoting proliferation and migration via E6/E7, while concurrently inducing an inhibitory effect through PPARA-mediated autophagy activation. The suppression of autophagy reversed the PPARA-driven inhibition, indicating a key role for the autophagy pathway. These findings suggest that PPARA targeting may be crucial in the pathogenesis of NIP, highlighting a complex interaction between HPV11 integration and host autophagy regulation.

HPV11 targeting PPARA regulates the autophagy to inhibit the occurrence and development of nasal inverted papilloma

Key Points

Abstract

Cite This Study