Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response

Key Points

• The enhanced vaccine response was linked to glucan-induced trained immunity in macrophages.
• Macrophages exhibited significant metabolic rewiring, which was essential for the improved response.
• Utilizing observations on glucan’s effects, this study underscores the potential of trained immunity.
• Implications suggest a refined approach to cancer vaccines, yet further validation in clinical settings is necessary.