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March 3, 2026European Journal of Pharmacology0 citations

Proton pump inhibitors accelerate vascular calcification via COX-2-mediated mitophagy inhibition in chronic kidney disease

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ZXZhuo-Chao XiongXLXiong-Zhi LiSYSi You

Key Points

  • Vascular calcification accelerates in chronic kidney disease due to proton pump inhibitors.
  • Inhibition of COX-2 leads to impaired mitophagy, contributing to this process.
  • Analysis across various models indicates a consistent association between medications and calcification levels.
  • Findings suggest a potential mechanistic link that could inform treatment strategies.
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Cite This Study

Xiong et al. (2026) studied this question.

synapsesocial.com/papers/69a75bf4c6e9836116a2435ehttps://doi.org/10.1016/j.ejphar.2026.178609
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