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Integrative analysis identifies DOK3's role in M2 macrophage polarization and glioblastoma progression, suggesting a novel therapeutic target.
This integrative analysis identifies DOK3 as a pivotal regulator of M2 macrophage polarization and a driver of glioblastoma progression. Together, immune subtyping and the simplified macrophage-based risk model represent complementary strategies, with the latter providing a practical tool for prognostic stratification. Targeting DOK3 offers a promising therapeutic strategy to reprogram the TME and improve clinical outcomes in patients with GBM.
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Ren et al. (2026) studied this question.
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