Assessment of endocrine disruptor impact on carbohydrate metabolism in the HepaRG human hepatic cell line

Key Points

• Carbohydrate metabolism is significantly impacted by endocrine disruptors, leading to altered metabolic pathways in HepaRG cells.
• Key evidence indicates a notable disruption in glucose uptake and glycogen synthesis in treated HepaRG cells compared to controls.
• Assessment using a human hepatic cell line provides insights into metabolic responses to endocrine disruptors affecting liver cells.
• Findings suggest potential implications for metabolic health, emphasizing the need to address endocrine disruptor exposure in public health.