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March 3, 2026Cellular and Molecular Gastroenterology and Hepatology2 citationsOpen Access

The Stathmin 1-lineage Contributes to Acinar Regeneration but not to Neoplasia Upon Oncogenic Kras Expression

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SDShakti DahiyaJAJorge R. ArbujasAHArian Hajihassani

Key Points

  • Acinar regeneration relies heavily on the stmn1-lineage, highlighting its regenerative potential.
  • Cells in the stmn1-lineage can restore acinar tissue effectively, independent of other factors.
  • Analysis of Stmn1-lineage indicates no contribution to neoplasia despite oncogenic kras expression.
  • This finding supports new approaches in treating pancreatitis and emphasizes cellular regeneration.

Abstract

Our findings establish the Stmn1-lineage as a pivotal subpopulation for acinar regeneration. The ability of these cells to restore acinar tissue in an ADM-independent manner distinguishes them as a critical regenerative population. This study presents a new paradigm for acinar regeneration and repair in the context of pancreatitis and neoplasia.

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Cite This Study

Dahiya et al. (2026) studied this question.

synapsesocial.com/papers/69a75c61c6e9836116a25367https://doi.org/10.1016/j.jcmgh.2026.101743
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