March 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

The protective effect of neurointerventional recanalization on the neurovascular unit in acute ischemic stroke and its correlation with serum GFAP and NfL levels

JLJu LuoXuzhou Medical College YYYijun YangQingdao University JZJingmin ZhouXuzhou Medical College

Key Points

Successful recanalization mitigates axonal injury and promotes neurovascular unit integrity, enhancing recovery.
Serum neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are promising biomarkers for stroke prognosis.
The association between recanalization and reduced neuroinflammation indicates potential therapeutic avenues for acute ischemic stroke.
Implications for clinical practice suggest that monitoring NfL and GFAP levels may help personalize stroke treatment strategies.

Abstract

Successful recanalization with MT is associated with mitigated axonal injury, astrocyte activation, and neuroinflammation, findings consistent with better preservation of NVU integrity. Serum NfL and GFAP represent promising biomarkers for predicting stroke prognosis and tailoring therapeutic strategies.

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