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March 3, 2026Alimentary Pharmacology & Therapeutics3 citations

Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain‐DDR Study

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AAAna AlberolaASAdolfo de SalazarAFA. Fuentes

Key Points

  • Hepatitis D virus seroprevalence was widely documented across various regions in Spain, highlighting national implementation success.
  • The expansion of double reflex testing demonstrates its feasibility across the country from 2022 to 2024, with mixed regional outcomes.
  • Assessment using retrospective data reveals ongoing challenges, particularly in addressing underdiagnosis in coinfected patients.
  • Standardized reflex protocols and training are crucial for ensuring consistent care and improving diagnosis efforts in the population.

Abstract

Between 2022 and 2024, double reflex diagnostic implementation expanded rapidly, demonstrating national feasibility and describing hepatitis D virus seroprevalence. However, regional inequities persist. Sustained uptake will require standardised reflex protocols, harmonization of viral load assays and continuous training to reduce underdiagnosis and improve care of coinfected patients.

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Cite This Study

Alberola et al. (2026) studied this question.

synapsesocial.com/papers/69a75c65c6e9836116a253e5https://doi.org/10.1111/apt.70543
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