Cryptococcal Antigenemia in South African Children Living With HIV

Alison Gifford; Rudzani Mashau; Ms Ruth Mpembe; David Khanyile; Thabo Maota; Mbali Dube; Boitumelo Kgoale; A. Warris; Nelesh P. Govender

doi:10.1097/inf.0000000000005154

January 28, 2026The Pediatric Infectious Disease Journal

Cryptococcal Antigenemia in South African Children Living With HIV

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Key Points

CrAg prevalence in children with CD4 <100 cells/µL stands at 4.7%, similar to 5.8% in adults.
Assessment using cryptococcal antigenemia screening guidelines emphasizes the need for inclusion of all children.
Comparative analysis shows that early screening could lead to better health outcomes for HIV-positive children.
Extending the screening guidelines highlights a crucial need for improved interventions in pediatric HIV care.

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Implication

Observational analysis reveals cryptococcal antigenemia prevalence in HIV-infected children, suggesting broader screening guidelines.

Abstract

CrAg prevalence in children with CD4 <100 cells/µL is comparable to adults (4.7% and 5.8%, respectively). CrAg screening guidelines should be extended to include all children to improve outcomes.

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Cite This Study

Gifford et al. (2026) studied this question.

synapsesocial.com/papers/69a75c90c6e9836116a25889 https://doi.org/10.1097/inf.0000000000005154

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Cryptococcal Antigenemia in South African Children Living With HIV

Key Points

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Implication

Abstract

Discussion

Cite This Study

Cryptococcal Antigenemia in South African Children Living With HIV

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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