The role of mitochondrial DNA-copy number in infectious disease: A bidirectional two-sample Mendelian randomization study

Key Points

• Mitochondrial dna-copy number significantly influences the risk of infectious disease, implicating a genetic pathway.
• The analysis involved two-sample mendelian randomization to establish a causal relationship across diverse populations.
• Observation highlights the importance of mitochondrial dna as a potential biomarker for infectious diseases.
• These findings suggest a novel avenue for therapeutic strategies targeting mitochondrial function in infection risk.