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March 3, 2026Frontiers in Molecular Biosciences0 citationsOpen Access

Antigen-specific T Cell precursor frequency influences the proliferation of stem-like T Cells in tumor-draining lymph nodes and anti-tumor immune responses

LWLiangnian WeiNanjing University of Chinese MedicineRCRong ChenNanjing University of Chinese MedicineKZKaijing ZhangNanjing University of Chinese Medicine

Key Points

  • Initial precursor frequencies of tumor-antigen-specific T cells significantly influence stem-like T cell dynamics.
  • Higher precursor frequencies lead to enhanced proliferation of stem-like T cells in tumor-draining lymph nodes.
  • The analysis uncovers a mechanism behind response variability to anti-PD-1 immunotherapy.
  • Understanding this link may provide insights for developing strategies against immune checkpoint blockade resistance.

Abstract

Our study provides the first direct in vivo evidence that the initial precursor frequency of tumor-antigen-specific T cell influences the stem-like T cell pool in TDLNs and thereby the efficacy of anti-PD-1 immunotherapy. This finding reveals a key upstream mechanism of response heterogeneity and offers a strategic rationale for overcoming ICB resistance.

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Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/69a75cb2c6e9836116a25cachttps://doi.org/10.3389/fmolb.2026.1771474
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