Mitochondrial dysfunction in MASH: Focusing on chronic inflammation and intercellular communication

Key Points

• Mitochondrial dysfunction is associated with chronic inflammation and affects cell signaling, revealing new pathways.
• Significant oxidative stress contributes to the disruption of intercellular communication and may exacerbate inflammation.
• Assessment using molecular pathway analysis highlights how chronic inflammation impacts mitochondrial function and signaling.
• Understanding these mechanisms could lead to targeted interventions for MASH, indicating possible therapeutic approaches.