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Observational analysis reveals a metabolic-immune axis connecting inflammation in chronic rhinosinusitis with asthma, suggesting new treatment avenues.
Our study reveals a highly conserved "metabolic-immune axis" that connects local tissue inflammation with systemic circulation, positioning metabolic dysregulation as a central hub in the unified airway disease model for CRSwA. These findings offer new perspectives for developing serum-based diagnostic markers and metabolically-targeted therapies for this challenging clinical condition.
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Peng et al. (2026) studied this question.
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