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March 3, 2026Neurogastroenterology & Motility1 citationsOpen Access

Altered Duodenal Mucosa‐Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host‐Microbiome Homeostasis

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EHEmily C. HoedtGBGrace L. BurnsSKSeungha Kang

Key Points

  • Patients with functional dyspepsia show distinct alterations in duodenal microbiota, hinting at underlying issues.
  • Immune profiles in these patients differ significantly from healthy controls, highlighting a potential mechanism of disease.
  • Analysis suggests that host-microbiome homeostasis is disrupted in functional dyspepsia patients, affecting immune response.
  • This study indicates the need for further research on microbiota's role in functional dyspepsia and potential therapeutic targets.

Abstract

Our findings contribute to a growing body of evidence, indicating FD patients exhibit distinct alterations in d-MAM and immune profiles compared to controls. Furthermore, the immune-microbiome associations within control populations were absent in FD patients, suggesting a loss of host-microbiome homeostasis that may contribute to FD pathophysiology.

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Cite This Study

Hoedt et al. (2026) studied this question.

synapsesocial.com/papers/69a75cd8c6e9836116a260fbhttps://doi.org/10.1111/nmo.70238
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