N-acetyl-cysteine alleviates nandrolone decanoate-induced hippocampal cell apoptosis in rats via reversing protein expressions of S1P1, Akt and FOXO3a signaling pathway

Alireza Shirpoor; Zahra Zarrini; Roya NADERI

doi:10.1016/j.steroids.2026.109759

January 28, 2026Steroids

N-acetyl-cysteine alleviates nandrolone decanoate-induced hippocampal cell apoptosis in rats via reversing protein expressions of S1P1, Akt and FOXO3a signaling pathway

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Key Points

N-acetyl-cysteine successfully decreases hippocampal cell apoptosis, pointing to potential therapeutic effects.
Protein expression levels of S1P1, Akt, and FOXO3a are significantly reversed with N-acetyl-cysteine treatment.
The study employs a control group for comparison of treatment effects in rat models exposed to nandrolone decanoate.
The findings highlight the need for further exploration of this intervention in preventing neuronal damage.

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Implication

Observational analysis reveals N-acetyl-cysteine reduces hippocampal cell apoptosis in rats, suggesting a protective role against nandrolone decanoate toxicity.

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Shirpoor et al. (2026) studied this question.

synapsesocial.com/papers/69a75ce7c6e9836116a262a0 https://doi.org/10.1016/j.steroids.2026.109759

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N-acetyl-cysteine alleviates nandrolone decanoate-induced hippocampal cell apoptosis in rats via reversing protein expressions of S1P1, Akt and FOXO3a signaling pathway

Key Points

No abstract yet

Implication

Discussion

Cite This Study

N-acetyl-cysteine alleviates nandrolone decanoate-induced hippocampal cell apoptosis in rats via reversing protein expressions of S1P1, Akt and FOXO3a signaling pathway

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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