Abstract

In our case—a 39-year-old adult with severe oral and ocular mucositis, pharyngeal ulceration, and confirmed M. pneumoniae co-infection with Rhino/Enterovirus—early initiation of systemic corticosteroids, alongside targeted antibiotic therapy, facilitated rapid improvement and recovery. The presentation aligned with RIME’s distinguishing features and highlights the importance of timely diagnosis and differentiation from SJS/TEN and other diseases such as HIV or Syphilis to avoid unnecessary discontinuation of medications or over-treatment.

Key Points

• Rapid improvement in symptoms occurred with early systemic corticosteroids initiation and targeted antibiotic therapy.
• The oral and ocular mucositis with pharyngeal ulceration indicates the need for prompt intervention to prevent complications.
• Differentiating reactive infectious mucocutaneous eruption from similar conditions like SJS/TEN is crucial for effective treatment.
• Timely diagnosis may reduce unnecessary medication discontinuation and prevent over-treatment, especially in co-infection scenarios.