March 3, 2026The Clinical Respiratory Journal0 citationsOpen Access

Safety and Efficacy of Noninvasive Ventilation in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Decreased Level of Consciousness: A Retrospective Study

IFIrma Sofia FabbriUniversity of Ferrara TPTeresa Bruna PaganoUniversity of Milan YDYuri DarinUniversity of Ferrara

Key Points

Successful outcomes were observed in most patients receiving noninvasive ventilation.
Key predictive parameters included initial GCS, blood pressure, and blood gas profiles.
This retrospective analysis involved patients with chronic obstructive pulmonary disease and significant neurological impairment.
Findings highlight that careful assessment can improve treatment efficacy for this patient population.

Abstract

NIV was feasible and associated with successful outcomes in a majority of patients with AECOPD and moderate to severe neurological impairment. Specific parameters, including initial GCS, blood pressure, SpO2, and blood gas profiles, can help predict outcomes and treatment efficacy.

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