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March 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Ellagic Acid Alleviates Abnormal Fat Reduction by Activating the RXRβ–PPARγ Pathways in a CT26 Tumour‐Induced Cachexia Mouse Model

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WPWoo Yong ParkBKBeomsu KimGSGahee Song

Key Points

  • Ellagic acid alleviates cancer cachexia-induced fat loss, demonstrating significant therapeutic potential.
  • The key metric shows a reduction in abnormal fat reduction associated with cachexia in mouse model.
  • Observational analysis in a CT26 tumour-induced cachexia mouse model highlights the RXRβ-PPARγ pathway activation.
  • This may enable new treatments for cachexia, given the promising effects observed in the mouse model.

Abstract

EA mitigates cancer cachexia-induced fat loss by the activation of the RXRβ-PPARγ pathway. These findings present EA as a potential pharmacological agent to improve the abnormal fat reduction and muscle dysfunction associated with cachexia.

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Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/69a75cf7c6e9836116a264c9https://doi.org/10.1002/jcsm.70176
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