Obacunone mitigates cisplatin-induced ototoxicity by activating CRHBP-mediated autophagy

Key Points

• Obacunone significantly reduces cisplatin-induced ototoxicity, indicating a protective effect.
• The intervention exhibited a decrease in ototoxic effects by 40% after treatment with obacunone.
• Assessment of the mechanism revealed the activation of CRHBP-mediated autophagy as a key factor.
• These findings highlight potential therapeutic avenues for reducing chemotherapy-related hearing loss.