March 3, 2026Stem Cells International1 citationsOpen Access

Overexpression of IL‐10 in Adipose Mesenchymal Stem Cells Promotes Wound Healing in Diabetic Mice

HZHui ZhaoChinese Academy of Medical Sciences & Peking Union Medical College FSFeng SongChinese Academy of Medical Sciences & Peking Union Medical College LOLong OuyangChinese Academy of Medical Sciences & Peking Union Medical College

Key Points

Wound healing is significantly enhanced by adipose mesenchymal stem cells overexpressing IL-10, improving tissue repair processes.
The study found that this mechanism results in reduced inflammatory responses and greater fibroblast migration, aiding recovery.
Analyzed the effects of IL-10 on various cellular behaviors in a diabetic mouse model, showing a clear promotion of healing.
These findings imply that targeting IL-10 could benefit diabetic wound management, although further studies are needed.

Abstract

ADSCs that overexpress IL-10 promote wound healing in diabetic mice by reducing inflammatory responses, enhancing growth factor secretion, and increasing the migration of fibroblasts and epidermal cells.

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