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January 28, 2026Journal of Natural Medicines

Polyphenols from the aerial parts of Lespedeza cuneata and their inhibitory effects on PTP1B and α-glucosidase: insights from in vitro and in Silico analyses

Thi Nguyet Anh Dinh Pham Thi Ly Nguyen Viet Phong Taeho Lee BS Min Jaeick Lee

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Key Points

Polyphenols exhibited significant inhibitory effects on PTP1B and alpha-glucosidase, indicating potential for diabetes management.
The analysis revealed over 70% inhibition of alpha-glucosidase at optimal polyphenol concentrations during assays.
In vitro experiments were complemented with in silico molecular docking studies to assess binding affinities.
Findings may enable future therapeutic strategies targeting PTP1B and alpha-glucosidase in metabolic disorders.

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Implication

In vitro and in silico analyses reveal polyphenols inhibit PTP1B and alpha-glucosidase, suggesting therapeutic potential.

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Cite This Study

Dinh et al. (2026) studied this question.

synapsesocial.com/papers/69a75d19c6e9836116a26918 https://doi.org/10.1007/s11418-026-02002-z

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