Polyphenols from the aerial parts of Lespedeza cuneata and their inhibitory effects on PTP1B and α-glucosidase: insights from in vitro and in Silico analyses

Key Points

• Polyphenols exhibited significant inhibitory effects on PTP1B and alpha-glucosidase, indicating potential for diabetes management.
• The analysis revealed over 70% inhibition of alpha-glucosidase at optimal polyphenol concentrations during assays.
• In vitro experiments were complemented with in silico molecular docking studies to assess binding affinities.
• Findings may enable future therapeutic strategies targeting PTP1B and alpha-glucosidase in metabolic disorders.