Evaluating sFlt-1/PLGF Ratio and Uterine Artery Doppler Indices for Early Detection and Prevention of Preeclampsia in High-Risk Women: A Prospective Cohort Study in a Tertiary Teaching Hospital of Uttar Pradesh

Nidhi Gupta; Akrishti Gupta

doi:10.1007/s13224-025-02327-x

January 28, 2026The Journal of Obstetrics and Gynecology of India

Evaluating sFlt-1/PLGF Ratio and Uterine Artery Doppler Indices for Early Detection and Prevention of Preeclampsia in High-Risk Women: A Prospective Cohort Study in a Tertiary Teaching Hospital of Uttar Pradesh

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Key Points

Preeclampsia can be detected earlier using sFlt-1 and PLGF ratios, and uterine artery Doppler measurements may enhance predictive accuracy.
The study found significant correlations between the sFlt-1/PLGF ratio and the occurrence of preeclampsia in high-risk females undergone monitoring.
Conducted as a prospective cohort study at a tertiary teaching hospital, focusing on specific Doppler indices and biomarker levels.
These findings may lead to better risks stratification and intervention strategies for women at high risk of preeclampsia.

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Implication

Cohort study evaluates sFlt-1/PLGF ratio and uterine artery Doppler indices for early preeclampsia detection in high-risk women, suggesting improved outcomes.

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Gupta et al. (2026) studied this question.

synapsesocial.com/papers/69a75d29c6e9836116a26be6 https://doi.org/10.1007/s13224-025-02327-x

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Evaluating sFlt-1/PLGF Ratio and Uterine Artery Doppler Indices for Early Detection and Prevention of Preeclampsia in High-Risk Women: A Prospective Cohort Study in a Tertiary Teaching Hospital of Uttar Pradesh

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Evaluating sFlt-1/PLGF Ratio and Uterine Artery Doppler Indices for Early Detection and Prevention of Preeclampsia in High-Risk Women: A Prospective Cohort Study in a Tertiary Teaching Hospital of Uttar Pradesh

Key Points

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