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Empirical analysis reveals genetic and phenotypic factors impacting sustained antidepressant use in major depressive disorder, suggesting new treatment pathways.
This study found that phenotypic factors were associated with sustained antidepressant use and treatment complexity. PGSs for traits studied were associated with treatment complexity but showed little association with sustained-use 360 groups. These findings support further research to guide treatment selection and to identify patients at risk of difficult-to-treat depression, informing precision psychiatry and early intervention in MDD.
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Walker et al. (2026) studied this question.
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