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Web-based randomized controlled trial shows no improvement in ART adherence among youth with HIV, suggesting further study design considerations are necessary.
The YouTHrive intervention did not improve ART adherence or HIV viral load in this sample of youth. However, substantial changes to study procedures made in response to the COVID-19 pandemic may have contributed to these findings. Teams conducting similar studies in the future should consider ways of mitigating the impacts of possible future pandemics or similar disruptions early in their timeline to consider the impacts of changes to the study.Trial Registration: The study is registered as a clinical trial (clinicaltrials.gov, NCT03149757).
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Horvath et al. (2026) studied this question.
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