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March 3, 2026World Journal of PsychiatryOpen Access

Acupuncture on 5-hydroxytryptamine levels and clinical outcomes in depression: A systematic review and meta-analysis of randomized controlled trials

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Authors

YWYi WangChinese Academy of Medical Sciences & Peking Union Medical CollegePWPeng-Tao WuCommunity Health CenterIPIttipalanukul PenpatShanghai University of Traditional Chinese Medicine

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Implication

Meta-analysis demonstrates acupuncture improves clinical outcomes in depression, indicating potential therapeutic benefits.

Key Points

  • Acupuncture significantly improves clinical outcomes in depression, particularly symptoms and anxiety.
  • Meta-analysis of randomized controlled trials indicates a notable effect on 5-hydroxytryptamine levels.
  • Systematic review highlights the efficacy of acupuncture in alleviating antidepressant side effects across various studies.
  • Caution is warranted due to the low quality of included randomized controlled trials.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a75d75c6e9836116a2784ehttps://doi.org/10.5498/wjp.v16.i2.113049
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