Unveiling the protective mechanisms of Pipa Qingfei Decoction in pulmonary arterial hypertension: Insights from network pharmacology, metabolomics and Mendelian randomization

Puntos clave

• Pipa Qingfei Decoction shows significant protective mechanisms against pulmonary arterial hypertension.
• Key evidence includes alterations in metabolomics linked to pulmonary arterial hypertension, highlighting crucial pathways.
• Analysis combining network pharmacology and Mendelian randomization supports the therapeutic efficacy of Pipa Qingfei Decoction.
• These findings suggest a potential new treatment avenue for managing pulmonary arterial hypertension.