March 3, 2026Open Access

Sex-Based Differences in the Effect of Short Dual Antiplatelet Therapy Followed by Prasugrel Monotherapy in High-Bleeding-Risk Patients After Percutaneous Coronary Intervention

Key Points

Short dual antiplatelet therapy significantly reduces bleeding without increasing ischemic events in high bleeding risk patients.
While conventional DAPT is common, the role of prasugrel monotherapy post-therapy remains uncertain among sexes.

Structured PICO

Does short DAPT followed by prasugrel monotherapy have sex-based differences in outcomes compared with conventional DAPT in high-bleeding-risk patients after PCI?

Population

Patients at high bleeding risk (HBR) after percutaneous coronary intervention (PCI)

Intervention

Short dual antiplatelet therapy (DAPT) followed by prasugrel monotherapy

Comparator

Conventional DAPT strategy

Abstract

Background: In patients at high bleeding risk (HBR), short dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) reduces bleeding without increasing ischemic events. However, the sex-based differences in the effects of short DAPT strategy followed by prasugrel monotherapy compared with conventional DAPT strategy remain unclear.

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