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January 1, 2026Gastroenterology

Vonoprazan-Tetracycline Dual Regimen as Rescue Therapy for Helicobacter pylori Infection: Randomized Controlled Trial

Wen Gao Jingwen Li Guibin Yang Shiyu Du Tingsheng Ling Xuezhi Zhang Hui Ye Yihong Xiong Yuling Tian Jianxiang Liu Binbin Liu Chi Wang Hong Cheng

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Key Points

The dual regimen shows significant effectiveness in eradicating helicobacter pylori infections, offering a new option for difficult cases.
Eighty-five percent of participants experienced successful eradication after treatment, highlighting the regimen's potential.
In a randomized controlled trial, the vonoprazan-tetracycline combination was tested against standard therapies.
Findings suggest that this new approach may improve treatment outcomes for patients with persistent infections.

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Implication

Randomized controlled trial assesses the effectiveness of dual therapy in treating Helicobacter pylori infections, suggesting new treatment options.

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Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69a75d89c6e9836116a27ada https://doi.org/10.1053/j.gastro.2026.01.008

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-AnalysisMeta-Analysis · 2017 · 3,379 citations
240 years after the discovery of Helicobacter Pylori : Performing optimized “subtraction” for clinical eradicationMeta-Analysis · 2025 · 3 citations
3Comparative Efficacy and Safety of Potassium-Competitive Acid Blocker-Based Dual, Triple, and Quadruple Regimens for First-Line Helicobacter pylori Infection Treatment: A Systematic Review and Network Meta-AnalysisRCT · 2024 · 25 citations
4Effects of amoxicillin dosage on cure rate, gut microbiota, and antibiotic resistome in vonoprazan and amoxicillin dual therapy for Helicobacter pylori: a multicentre, open-label, non-inferiority randomised controlled trialRandomized Controlled Trial · 2024 · 42 citations
5Management of <i>Helicobacter pylori</i> infection: the Maastricht VI/Florence consensus reportOriginal Research · 2022 · 1,541 citations

More related papers

Simplified <i>Helicobacter pylori</i> therapy for patients with penicillin allergy: a randomised controlled trial of vonoprazan-tetracycline dual therapy2024
A real‐world exploratory study on the feasibility of vonoprazan and tetracycline dual therapy for the treatment of <i>Helicobacter pylori</i> infection in special populations with penicillin allergy or failed in previous amoxicillin‐containing therapies2023
Meta‐analysis of three‐in‐one single capsule bismuth‐containing quadruple therapy for the eradication of <i>Helicobacter pylori</i>2019

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