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March 3, 2026Scientific Reports3 citationsOpen Access

Optimization of the extraction process of Sanhuang Qingre Formula by integrating response surface methodology, grey correlation analysis, and machine learning

QCQisong ChenHunan University of Traditional Chinese MedicineMPMeng PanHunan University of Traditional Chinese MedicineXHXinyue HuHunan University of Traditional Chinese Medicine

Key Points

  • This optimization approach significantly enhances the extraction yield of Sanhuang Qingre Formula, leading to better herbal product quality.
  • Using response surface methodology and machine learning, researchers achieved optimal conditions for maximum extraction efficiency.
  • Integration of grey correlation analysis allows for a precise evaluation of various influence factors on the extraction process.
  • This multi-method approach may enable herbal companies to produce higher-quality products, enhancing therapeutic benefits.
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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69a75dabc6e9836116a27dd1https://doi.org/10.1038/s41598-026-37751-0
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